Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 30 Researches
7.6
USERS' SCORE
Good
Based on 7 Reviews
8.1
Supplement Facts
Serving Size: 1 tablet
Amount Per Serving
%DV
Vitamin B6 (as pyridoxine HCl)
2 mg
118%
Folate (as folic acid)
400 mcg DFE
100%
Vitamin B12 (as methylcobalamin)
1000 mcg
41667%
Top Medical Research Studies
8
We explored the potential of high doses of vitamin B12 to protect against heart damage caused by ischemia/reperfusion injury. By researching mice subjected to heart injury, we found that vitamin B12 showed promising effects in reducing oxidative stress and improving heart function.
Our findings suggest that this vitamin works through specific pathways that lessen inflammation and cell death in heart tissue. However, more studies are needed to fully understand its therapeutic value in treating heart disease.
Our findings suggest that this vitamin works through specific pathways that lessen inflammation and cell death in heart tissue. However, more studies are needed to fully understand its therapeutic value in treating heart disease.
Read More
We conducted a case-control study to look into how maternal folic acid supplementation affects the risk of congenital heart disease (CHD) in children and whether genetic factors, specifically MTRR gene polymorphisms, play a role in this relationship.
Our research involved 595 children diagnosed with CHD and 605 healthy children. By using a multivariate logistic regression model, we were able to assess the impact of maternal folate intake and the offspring's genetic profiles on the likelihood of developing CHD and its various subtypes.
The findings were quite striking. We observed that children whose mothers took folic acid during pregnancy showed a significantly reduced risk of CHD. Specifically, this included notable reductions in certain types of heart defects such as atrial septal defect and ventricular septal defect. Interestingly, specific polymorphisms in the MTRR gene were also linked to an increased risk of CHD.
Most importantly, we found that when mothers supplemented with folic acid, it appeared to mitigate some of the risks associated with genetic variants in their children. However, we recognize the need for additional studies with larger populations and different designs to confirm these important findings.
Our research involved 595 children diagnosed with CHD and 605 healthy children. By using a multivariate logistic regression model, we were able to assess the impact of maternal folate intake and the offspring's genetic profiles on the likelihood of developing CHD and its various subtypes.
The findings were quite striking. We observed that children whose mothers took folic acid during pregnancy showed a significantly reduced risk of CHD. Specifically, this included notable reductions in certain types of heart defects such as atrial septal defect and ventricular septal defect. Interestingly, specific polymorphisms in the MTRR gene were also linked to an increased risk of CHD.
Most importantly, we found that when mothers supplemented with folic acid, it appeared to mitigate some of the risks associated with genetic variants in their children. However, we recognize the need for additional studies with larger populations and different designs to confirm these important findings.
Read More
8
We explored the effects of pyridoxamine (PM), a form of vitamin B6, on heart health in a study involving male rats. These rats were divided into two groups: one received a standard diet, while the other was fed a Western diet known to induce prediabetes. To see how PM might help, we gave one group of rats on the Western diet an additional PM supplement through their drinking water for 18 weeks.
Throughout the study, we measured glucose levels and evaluated heart function using echocardiography, alongside analyzing heart tissue for any changes. Remarkably, the rats that received PM showed less increase in fasting blood glucose compared to those on the Western diet alone. Additionally, the PM treatment seemed to prevent some heart enlargement that typically occurs alongside unhealthy diets.
Furthermore, PM was effective in limiting collagen buildup within the heart tissue, which is often a marker of heart stress or damage. We also noted a reduction in substances related to oxidative stress, suggesting that PM might protect against heart damage by reducing harmful compounds. In summary, our findings suggest that pyridoxamine may help alleviate issues related to heart structure and stress in rats at risk of developing heart disease due to prediabetes.
Throughout the study, we measured glucose levels and evaluated heart function using echocardiography, alongside analyzing heart tissue for any changes. Remarkably, the rats that received PM showed less increase in fasting blood glucose compared to those on the Western diet alone. Additionally, the PM treatment seemed to prevent some heart enlargement that typically occurs alongside unhealthy diets.
Furthermore, PM was effective in limiting collagen buildup within the heart tissue, which is often a marker of heart stress or damage. We also noted a reduction in substances related to oxidative stress, suggesting that PM might protect against heart damage by reducing harmful compounds. In summary, our findings suggest that pyridoxamine may help alleviate issues related to heart structure and stress in rats at risk of developing heart disease due to prediabetes.
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Most Useful Reviews
9
Improves heart metabolism
B12 is in a natural form that enhances metabolism, lowers cholesterol, and supports digestion. It's also involved in nutrient synthesis and heart functioning. The small tablets have a slightly sour taste and are suitable for those over 50 to maintain cognitive health.
Read More
9
Normalises heart function
Easy to take; the tablets dissolve quickly with a lovely aftertaste. This supplement benefits the heart and blood vessels, and seems to have normalised my menstrual cycle, making it more manageable.
Read More
6
Supports heart health
6 people found this helpful
B12 in a digestible form. It boosts metabolism, aids in lowering cholesterol, and supports the digestive process. It also plays a role in nutrient synthesis and heart health. The tablets are small and have a slightly sour taste. Suitable for those over 50 to prevent memory issues. Acne may be a potential side effect.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 30 Researches
7.6
- All Researches
9.5
We explored the effects of folate, a form of vitamin B, on heart problems associated with TANGO2-deficiency disorder (TDD). This genetic condition can lead to dangerous heart rhythms that don’t respond well to standard treatments. To dive deeper into this issue, we established patient-derived heart cells, known as iPSC-CMs, to mimic the heart abnormalities seen in TDD.
In our observations, we found that high doses of folate almost completely eliminated arrhythmias in these heart cells. Interestingly, our clinical observations revealed that TDD patients taking multivitamins, particularly those high in B vitamins, experienced a significant reduction in cardiac crises. This suggests that folate may play a critical role in protecting against these life-threatening heart issues.
Our findings not only highlight the potential of folate as an effective treatment but also emphasize the importance of considering dietary supplements in managing cardiac risks in patients with TDD. Thus, we believe that boosting folate intake could offer a valuable strategy to enhance heart health in those affected by this disorder.
In our observations, we found that high doses of folate almost completely eliminated arrhythmias in these heart cells. Interestingly, our clinical observations revealed that TDD patients taking multivitamins, particularly those high in B vitamins, experienced a significant reduction in cardiac crises. This suggests that folate may play a critical role in protecting against these life-threatening heart issues.
Our findings not only highlight the potential of folate as an effective treatment but also emphasize the importance of considering dietary supplements in managing cardiac risks in patients with TDD. Thus, we believe that boosting folate intake could offer a valuable strategy to enhance heart health in those affected by this disorder.
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9
We explored the effects of vitamin B6 (pyridoxine) on heart health, specifically looking at its protective qualities against angina provoked by vasopressin in a rat model. Vasopressin was administered to observe its impact on heart function, which included elevated stress on the heart indicated by changes on the electrocardiogram and increased cardiac enzymes.
The study found that when we gave rats pyridoxine in varying doses, it effectively reduced the ST elevation and heart rate changes caused by vasopressin. Notably, higher doses of pyridoxine (7 mg/kg) showed significant protective effects, outperforming both amlodipine and isosorbide. In addition, we observed that pyridoxine at these doses helped prevent cardiac tissue damage and improved heart structure.
Interestingly, while combining pyridoxine with amlodipine led to a trend of increased adverse cardiovascular events, the results underscored the potential of vitamin B6 in enhancing heart health. It appears vitamin B6 may work by improving certain functions in the body that support heart health, such as better blood vessel function and reduced levels of harmful substances.
Overall, our findings suggest that vitamin B6 could serve as a promising agent in preventing coronary heart disease, but more research is necessary to fully explore its benefits and practical applications in humans.
The study found that when we gave rats pyridoxine in varying doses, it effectively reduced the ST elevation and heart rate changes caused by vasopressin. Notably, higher doses of pyridoxine (7 mg/kg) showed significant protective effects, outperforming both amlodipine and isosorbide. In addition, we observed that pyridoxine at these doses helped prevent cardiac tissue damage and improved heart structure.
Interestingly, while combining pyridoxine with amlodipine led to a trend of increased adverse cardiovascular events, the results underscored the potential of vitamin B6 in enhancing heart health. It appears vitamin B6 may work by improving certain functions in the body that support heart health, such as better blood vessel function and reduced levels of harmful substances.
Overall, our findings suggest that vitamin B6 could serve as a promising agent in preventing coronary heart disease, but more research is necessary to fully explore its benefits and practical applications in humans.
Read More
9
We explored the effects of vitamin B6 (VB6) on heart recovery after an acute myocardial infarction (AMI). The study aimed to determine if VB6 could promote angiogenesis, the process of new blood vessel formation, which is crucial for healing the heart after such an event.
To investigate this, we looked at the ability of VB6 to enhance cell migration and tube formation in human umbilical vein endothelial cells, which are key players in the formation of blood vessels. Our results showed that VB6 not only encouraged these processes but also increased the phosphorylation of AMPK, a protein that plays a vital role in cellular energy regulation.
Importantly, these beneficial effects of VB6 on cell behavior were found to depend on AMPK activation. When we used specific inhibitors to block AMPK, the positive changes from VB6 were no longer observed. Additionally, in an animal model, long-term supplementing with VB6 led to significant improvements in heart function, more new blood vessel growth, and reduced inflammation markers in mice after AMI.
In summary, our findings suggest that vitamin B6 could be an effective support for heart recovery due to its role in promoting angiogenesis through AMPK activation following heart attacks. Given that VB6 shows promise in limiting ischemic heart injury, it could be a valuable addition to existing heart disease treatments.
To investigate this, we looked at the ability of VB6 to enhance cell migration and tube formation in human umbilical vein endothelial cells, which are key players in the formation of blood vessels. Our results showed that VB6 not only encouraged these processes but also increased the phosphorylation of AMPK, a protein that plays a vital role in cellular energy regulation.
Importantly, these beneficial effects of VB6 on cell behavior were found to depend on AMPK activation. When we used specific inhibitors to block AMPK, the positive changes from VB6 were no longer observed. Additionally, in an animal model, long-term supplementing with VB6 led to significant improvements in heart function, more new blood vessel growth, and reduced inflammation markers in mice after AMI.
In summary, our findings suggest that vitamin B6 could be an effective support for heart recovery due to its role in promoting angiogenesis through AMPK activation following heart attacks. Given that VB6 shows promise in limiting ischemic heart injury, it could be a valuable addition to existing heart disease treatments.
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9
We examined how vitamin B-6 might play a role in preventing heart failure with preserved ejection fraction (HFpEF), a condition that often results from changes in heart-related immune cells called macrophages. Our research was based on a mouse model that mimicked HFpEF through a high-fat diet paired with a specific supplement. By monitoring heart function using various imaging techniques, as well as examining heart tissue for changes, we gathered important insights into vitamin B-6's potential benefits.
We found that when vitamin B-6 was added to the diet of mice prone to HFpEF, it significantly improved several heart failure symptoms. There were notable enhancements in heart function, reducing pressure in the heart and allowing for better exercise capacity. However, we made a crucial discovery: the positive effects of vitamin B-6 were diminished when we examined mice lacking a specific protein called DOK3. This suggests that DOK3 is key to vitamin B-6’s success in mitigating heart failure symptoms.
Essentially, our findings indicate that vitamin B-6 might lower the risk of heart failure by halting harmful changes in cardiac macrophages thanks to its ability to boost DOK3 signaling. This research offers exciting possibilities for a new therapeutic approach aimed at improving heart health and managing HFpEF effectively.
We found that when vitamin B-6 was added to the diet of mice prone to HFpEF, it significantly improved several heart failure symptoms. There were notable enhancements in heart function, reducing pressure in the heart and allowing for better exercise capacity. However, we made a crucial discovery: the positive effects of vitamin B-6 were diminished when we examined mice lacking a specific protein called DOK3. This suggests that DOK3 is key to vitamin B-6’s success in mitigating heart failure symptoms.
Essentially, our findings indicate that vitamin B-6 might lower the risk of heart failure by halting harmful changes in cardiac macrophages thanks to its ability to boost DOK3 signaling. This research offers exciting possibilities for a new therapeutic approach aimed at improving heart health and managing HFpEF effectively.
Read More
9
We focused on how pyridoxamine, a form of vitamin B6, impacts heart health during treatment with doxorubicin, a common cancer drug. In an experimental setup with Sprague Dawley rats, we observed that those receiving doxorubicin experienced a decrease in heart function, specifically a reduced left ventricular ejection fraction, and an increase in heart volume.
Notably, when we added pyridoxamine to the treatment, these harmful effects were significantly lessened. The rats that took pyridoxamine alongside doxorubicin maintained better heart function compared to those who only received doxorubicin. This suggests that pyridoxamine acts as a protective agent for the heart, countering some of the negative impacts caused by doxorubicin.
However, we also investigated how doxorubicin and pyridoxamine affected breast cancer cells in the lab. While doxorubicin effectively reduced cancer cell viability and increased cell death, pyridoxamine didn’t change these outcomes. This indicates that while pyridoxamine can preserve heart health during chemotherapy, it doesn’t interfere with the cancer-fighting effects of doxorubicin.
Overall, this research highlights pyridoxamine's promising role as a cardioprotectant during cancer treatment, allowing for heart preservation without diminishing the effectiveness of anticancer therapies.
Notably, when we added pyridoxamine to the treatment, these harmful effects were significantly lessened. The rats that took pyridoxamine alongside doxorubicin maintained better heart function compared to those who only received doxorubicin. This suggests that pyridoxamine acts as a protective agent for the heart, countering some of the negative impacts caused by doxorubicin.
However, we also investigated how doxorubicin and pyridoxamine affected breast cancer cells in the lab. While doxorubicin effectively reduced cancer cell viability and increased cell death, pyridoxamine didn’t change these outcomes. This indicates that while pyridoxamine can preserve heart health during chemotherapy, it doesn’t interfere with the cancer-fighting effects of doxorubicin.
Overall, this research highlights pyridoxamine's promising role as a cardioprotectant during cancer treatment, allowing for heart preservation without diminishing the effectiveness of anticancer therapies.
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User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improves heart metabolism
B12 is in a natural form that enhances metabolism, lowers cholesterol, and supports digestion. It's also involved in nutrient synthesis and heart functioning. The small tablets have a slightly sour taste and are suitable for those over 50 to maintain cognitive health.
Read More
9
Normalises heart function
Easy to take; the tablets dissolve quickly with a lovely aftertaste. This supplement benefits the heart and blood vessels, and seems to have normalised my menstrual cycle, making it more manageable.
Read More
6
Supports heart health
6 people found this helpful
B12 in a digestible form. It boosts metabolism, aids in lowering cholesterol, and supports the digestive process. It also plays a role in nutrient synthesis and heart health. The tablets are small and have a slightly sour taste. Suitable for those over 50 to prevent memory issues. Acne may be a potential side effect.
Read More
9
Strengthens heart vessels
Vegan B12 with folic acid and B6 is effective. It helps produce red blood cells and supports nerve health. Folic acid is vital for heart function and reducing heart disease risk. After recovery from Covid, I realised I needed this for my vascular health.
Read More
7.5
Boosts heart energy
A good product for heart health that provides an energy boost after consumption.
Read More
Frequently Asked Questions
7.5
Boosts heart energy
A good product for heart health that provides an energy boost after consumption.
7.5
Supports heart well-being
Essential trace elements for heart health, nervous system, and overall well-being.
9
Improves heart metabolism
B12 is in a natural form that enhances metabolism, lowers cholesterol, and supports digestion. It's also involved in nutrient synthesis and heart functioning. The small tablets have a slightly sour taste and are suitable for those over 50 to maintain cognitive health.
9
Normalises heart function
Easy to take; the tablets dissolve quickly with a lovely aftertaste. This supplement benefits the heart and blood vessels, and seems to have normalised my menstrual cycle, making it more manageable.
9
Strengthens heart vessels
Vegan B12 with folic acid and B6 is effective. It helps produce red blood cells and supports nerve health. Folic acid is vital for heart function and reducing heart disease risk. After recovery from Covid, I realised I needed this for my vascular health.
7.5
Enhances heart function
1 people found this helpful
Excellent quality folic acid with vitamin B12, beneficial for women’s health and Parkinson’s disease. After taking it as recommended, I noticed a stable nervous system and improved metabolism. The capsules dissolve conveniently and have a pleasant taste.
7
Vitamin B12 may lower inflammation
We examined how vitamin B12 levels relate to heart disease risk by looking at inflammatory markers in 136 individuals at high risk. Our findings revealed that those with higher vitamin B12 had lower levels of IL-6 and CRP, both linked to inflammation.
To further validate our results, we studied aged mice and found similar trends. While these observations suggest vitamin B12 might help reduce inflammation, we indicate that further research is needed to fully understand its role in heart disease.
To further validate our results, we studied aged mice and found similar trends. While these observations suggest vitamin B12 might help reduce inflammation, we indicate that further research is needed to fully understand its role in heart disease.
8
We explored the potential of high doses of vitamin B12 to protect against heart damage caused by ischemia/reperfusion injury. By researching mice subjected to heart injury, we found that vitamin B12 showed promising effects in reducing oxidative stress and improving heart function.
Our findings suggest that this vitamin works through specific pathways that lessen inflammation and cell death in heart tissue. However, more studies are needed to fully understand its therapeutic value in treating heart disease.
Our findings suggest that this vitamin works through specific pathways that lessen inflammation and cell death in heart tissue. However, more studies are needed to fully understand its therapeutic value in treating heart disease.
5
We explored the relationship between serum levels of vitamin B12 and folate and cardiovascular disease (CVD) mortality in patients with type 2 diabetes. This large study analyzed data from over 8,000 individuals to identify risks associated with different levels of these vitamins.
Our findings showed that both low and high levels of vitamin B12, along with low folate, were linked to a higher chance of dying from heart disease. This suggests a complex role of these vitamins in heart health for those with diabetes.
Our findings showed that both low and high levels of vitamin B12, along with low folate, were linked to a higher chance of dying from heart disease. This suggests a complex role of these vitamins in heart health for those with diabetes.
7
We conducted an insightful study to understand how plasma vitamin B6, specifically its active form known as pyridoxal 5'-phosphate (PLP), might influence the risk of coronary heart disease (CHD). Our focus was on evaluating both overall effects and any notable differences between men and women.
In our research, we included 429 patients with diagnosed CHD and an equal number of controls, all matched for age, sex, and time of operation. By examining plasma PLP levels through sophisticated testing methods, we made some intriguing discoveries.
While we observed that higher levels of PLP were generally linked to a lower risk of CHD, this association strongly favored women. Specifically, each increase of 1 ng/mL in PLP was correlated with a 28% reduced risk of CHD in the overall group, and in women, this translated to a significant protection (odds ratio of 0.63). However, the same could not be said for men, where the results were not as clear-cut.
These findings reveal a noteworthy trend, suggesting that vitamin B6 may play a critical role in heart health for women, a connection that deserves further exploration. We believe this opens new avenues for understanding heart disease, especially among different genders.
In our research, we included 429 patients with diagnosed CHD and an equal number of controls, all matched for age, sex, and time of operation. By examining plasma PLP levels through sophisticated testing methods, we made some intriguing discoveries.
While we observed that higher levels of PLP were generally linked to a lower risk of CHD, this association strongly favored women. Specifically, each increase of 1 ng/mL in PLP was correlated with a 28% reduced risk of CHD in the overall group, and in women, this translated to a significant protection (odds ratio of 0.63). However, the same could not be said for men, where the results were not as clear-cut.
These findings reveal a noteworthy trend, suggesting that vitamin B6 may play a critical role in heart health for women, a connection that deserves further exploration. We believe this opens new avenues for understanding heart disease, especially among different genders.
References
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- Domínguez-López I, Kovatcheva M, Casas R, Toledo E, Fitó M, et al. Higher circulating vitamin B12 is associated with lower levels of inflammatory markers in individuals at high cardiovascular risk and in naturally aged mice. J Sci Food Agric. 2024;104:875. doi:10.1002/jsfa.12976
- Qin Y, Shi Y, Yu Q, Yang S, Wang Y, et al. Vitamin B12 alleviates myocardial ischemia/reperfusion injury via the SIRT3/AMPK signaling pathway. Biomed Pharmacother. 2023;163:114761. doi:10.1016/j.biopha.2023.114761
- Dhar I, Svingen GF, Bjørnestad EØ, Ulvik A, Saeed S, et al. B-vitamin Treatment Modifies the Mortality Risk Associated with Calcium Channel Blockers in Patients with Suspected Stable Angina Pectoris: A Prospective Cohort Study. Am J Clin Nutr. 2023;118:77. doi:10.1016/j.ajcnut.2023.04.033
- Ha AW, Kim WK, Kim SH. Cow's Milk Intake and Risk of Coronary Heart Disease in Korean Postmenopausal Women. Nutrients. 2022;14. doi:10.3390/nu14051092
- Liu Y, Geng T, Wan Z, Lu Q, Zhang X, et al. Associations of Serum Folate and Vitamin B12 Levels With Cardiovascular Disease Mortality Among Patients With Type 2 Diabetes. JAMA Netw Open. 2022;5:e2146124. doi:10.1001/jamanetworkopen.2021.46124
- Huang TH, Chang HH, Guo YR, Chang WC, Chen YF. Vitamin B Mitigates Thoracic Aortic Dilation in Marfan Syndrome Mice by Restoring the Canonical TGF-β Pathway. Int J Mol Sci. 2021;22. doi:10.3390/ijms222111737
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- Al-Khawlani MA, Al-Madhagi WM, Sabati AM, ALomaisi SAMA, Al-Najar M. Protective effects of pyridoxine, amlodipine, and their combination in a vasopressin-induced angina model in rats. Naunyn Schmiedebergs Arch Pharmacol. 2025. doi:10.1007/s00210-025-03905-6
- Wang XQ, Yin S, Wang QW, Bai WW, Tan RH, et al. Vitamin B6 allosterically activates AMPK to promote postischemic angiogenesis in mice. Eur J Pharmacol. 2025;993:177413. doi:10.1016/j.ejphar.2025.177413
- Li B, Hu M, Ma Y, Sun X, Wu D, et al. Association between Vitamin E, Vitamin B6, and Vitamin B12 with coronary heart disease. Sci Rep. 2024;14:19960. doi:10.1038/s41598-024-68413-8
- Song JW, Zhang ZS, Chen L, Wang QW, Xu JY, et al. Vitamin B-6 Prevents Heart Failure with Preserved Ejection Fraction Through Downstream of Kinase 3 in a Mouse Model. J Nutr. 2024;154:3031. doi:10.1016/j.tjnut.2024.08.006
- Agraib LM, Al-Shami I, Alkhatib B, Hasan H. The impact of energy releasing B-vitamin intake on indices of obesity and cardiac function: a cross-sectional study. F1000Res. 2023;12:1382.
- D'Haese S, Claes L, Jaeken E, Deluyker D, Evens L, et al. Pyridoxamine Alleviates Cardiac Fibrosis and Oxidative Stress in Western Diet-Induced Prediabetic Rats. Int J Mol Sci. 2024;25. doi:10.3390/ijms25158508
- Haesen S, Verghote E, Heeren E, Wolfs E, Deluyker D, et al. Pyridoxamine Attenuates Doxorubicin-Induced Cardiomyopathy without Affecting Its Antitumor Effect on Rat Mammary Tumor Cells. Cells. 2024;13. doi:10.3390/cells13020120
- Faingold II, Smolina AV, Soldatova YV, Poletaeva DA, Balakina AA, et al. Cardioprotective Effect of 2-Ethyl-3-Hydroxy-6-Methylpyridinium 2-Nitroxysuccinate Against Adrenaline/Hydrocortisone-Induced Myocardial Ischemia in Mice: Modulation of Free-Radical Processes in Biomembranes and Monoamine Oxidase A Activity. Cell Biochem Biophys. 2024;82:235. doi:10.1007/s12013-023-01203-7
- Sun RL, Wang HH, Gui ZC, Lin LB, Fan JX, et al. Protective effect of vitamin B against doxorubicin-induced cardiotoxicity by modulating NHE1 expression. J Biochem Mol Toxicol. 2023;37:e23403. doi:10.1002/jbt.23403
- Hanssen NMJ, Tikellis C, Pickering RJ, Dragoljevic D, Lee MKS, et al. Pyridoxamine prevents increased atherosclerosis by intermittent methylglyoxal spikes in the aortic arches of ApoE mice. Biomed Pharmacother. 2023;158:114211. doi:10.1016/j.biopha.2022.114211
- Bajic Z, Sobot T, Skrbic R, Stojiljkovic MP, Ponorac N, et al. Homocysteine, Vitamins B6 and Folic Acid in Experimental Models of Myocardial Infarction and Heart Failure-How Strong Is That Link?. Biomolecules. 2022;12. doi:10.3390/biom12040536
- Hu L, Li Y, Liu Z, Fan F, Xu B, et al. Association of Plasma Vitamin B6 With Coronary Heart Disease in Patients Undergoing Diagnostic Coronary Angiography: New Insight on Sex Differences. Front Cardiovasc Med. 2021;8:789669. doi:10.3389/fcvm.2021.789669
- Shah AK, Dhalla NS. Effectiveness of Some Vitamins in the Prevention of Cardiovascular Disease: A Narrative Review. Front Physiol. 2021;12:729255. doi:10.3389/fphys.2021.729255
- Evens L, Beliën H, D'Haese S, Haesen S, Verboven M, et al. Combinational Therapy of Cardiac Atrial Appendage Stem Cells and Pyridoxamine: The Road to Cardiac Repair?. Int J Mol Sci. 2021;22. doi:10.3390/ijms22179266
- Kumrungsee T, Yanaka N, Suda T, Kato N. Emerging cardioprotective mechanisms of vitamin B6: a narrative review. Eur J Nutr. 2022;61:605. doi:10.1007/s00394-021-02665-2
- Ruan X, Shang W, Lu J, Li Z, Yang J, et al. Maternal multivitamin supplementation mitigates the risk of fetal congenital heart disease associated with high indoor total volatile organic compounds exposure in east china: a case-control study. Environ Health. 2024;23:110. doi:10.1186/s12940-024-01150-7
- Li L, Ou J, Chen Y, Chen Q, Luo M, et al. Association of maternal folic acid supplementation and offspring MTRR gene polymorphism with congenital heart disease: a hospital-based case-control study in Han population. J Health Popul Nutr. 2024;43:220. doi:10.1186/s41043-024-00699-w
- Qu Y, Liu X, Lin S, Bloom MS, Wang X, et al. Maternal Serum Folate During Pregnancy and Congenital Heart Disease in Offspring. JAMA Netw Open. 2024;7:e2438747. doi:10.1001/jamanetworkopen.2024.38747
- Ma L, Zeng L, Wang X. MTHFR C677T gene polymorphism in patients with coronary heart disease and hypertension treated with enalapril and folic acid: implications for prognosis. Cell Mol Biol (Noisy-le-grand). 2024;70:142. doi:10.14715/cmb/2024.70.9.20
- Xu W, Cao Y, Stephens SB, Arredondo MJ, Chen Y, et al. Folate as a potential treatment for lethal ventricular arrhythmias in TANGO2-deficiency disorder. JCI Insight. 2024;9. doi:10.1172/jci.insight.171005
- Hjalmarsson C, Backelin C, Thoren A, Bergh N, Sloan JL, et al. Severe heart failure in a unique case of cobalamin-C-deficiency resolved with LVAD implantation and subsequent heart transplantation. Mol Genet Metab Rep. 2024;39:101089. doi:10.1016/j.ymgmr.2024.101089
- Mohan A, Kumar R, Kumar V, Yadav M. Homocysteine, Vitamin B12 and Folate Level: Possible Risk Factors in the Progression of Chronic Heart and Kidney Disorders. Curr Cardiol Rev. 2023;19:e090223213539. doi:10.2174/1573403X19666230209111854
